Niclosamide enhances ROS-mediated cell death through c-Jun activation

作者: Sae-lo-oom Lee , A-Rang Son , Jiyeon Ahn , Jie-Young Song

DOI: 10.1016/J.BIOPHA.2014.03.018

关键词: ApoptosisCytotoxic T cellReactive oxygen speciesCellNiclosamideProgrammed cell deathc-junBiologyRadiosensitizerPharmacology

摘要: … ROS were generated by another means. To this end, we used hydrogen peroxide (H 2 O 2 ), a strong ROS generator, and H1299 … is mediated by ROS, we used the ROS scavenger, N-…

参考文章(24)
Jonathan Ham, Carol Babij, Jonathan Whitfield, Curt M Pfarr, Dominique Lallemand, Moshe Yaniv, Lee L Rubin, A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death Neuron. ,vol. 14, pp. 927- 939 ,(1995) , 10.1016/0896-6273(95)90331-3
Jonathan Whitfield, Stephen J Neame, Luc Paquet, Ora Bernard, Jonathan Ham, Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release Neuron. ,vol. 29, pp. 629- 643 ,(2001) , 10.1016/S0896-6273(01)00239-2
Maria Vinciguerra, Ilaria Esposito, Salvatore Salzano, Antonio Madeo, Georg Nagel, Marcello Maggiolini, Adriana Gallo, Anna Maria Musti, Negative charged threonine 95 of c-Jun is essential for c-Jun N-terminal kinase-dependent phosphorylation of threonine 91/93 and stress-induced c-Jun biological activity. The International Journal of Biochemistry & Cell Biology. ,vol. 40, pp. 307- 316 ,(2008) , 10.1016/J.BIOCEL.2007.08.001
Kristen B. Otto, Sujeet S. Acharya, Victoria L. Robinson, Stress-activated kinase pathway alteration is a frequent event in bladder cancer Urologic Oncology: Seminars and Original Investigations. ,vol. 30, pp. 415- 420 ,(2012) , 10.1016/J.UROLONC.2010.03.002
So-Jung Park, Ji-Hyun Shin, Hee Kang, Jung-Jin Hwang, Dong-Hyung Cho, Niclosamide induces mitochondria fragmentation and promotes both apoptotic and autophagic cell death Journal of Biochemistry and Molecular Biology. ,vol. 44, pp. 517- 522 ,(2011) , 10.5483/BMBREP.2011.44.8.517
Matjaz Humar, Torsten Loop, Rene Schmidt, Alexander Hoetzel, Martin Roesslein, Nikolaos Andriopoulos, Heike L. Pahl, Klaus K. Geiger, Benedikt H.J. Pannen, The mitogen-activated protein kinase p38 regulates activator protein 1 by direct phosphorylation of c-Jun. The International Journal of Biochemistry & Cell Biology. ,vol. 39, pp. 2278- 2288 ,(2007) , 10.1016/J.BIOCEL.2007.06.013
Simon Morton, Roger J Davis, Ann McLaren, Philip Cohen, A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun. The EMBO Journal. ,vol. 22, pp. 3876- 3886 ,(2003) , 10.1093/EMBOJ/CDG388
Wenyan Lu, Cuihong Lin, Michael J. Roberts, William R. Waud, Gary A. Piazza, Yonghe Li, Niclosamide Suppresses Cancer Cell Growth By Inducing Wnt Co-Receptor LRP6 Degradation and Inhibiting the Wnt/β-Catenin Pathway PLoS ONE. ,vol. 6, pp. e29290- ,(2011) , 10.1371/JOURNAL.PONE.0029290
A Madeo, M Vinciguerra, R Lappano, M Galgani, A Gasperi-Campani, M Maggiolini, A M Musti, c-Jun activation is required for 4-hydroxytamoxifen-induced cell death in breast cancer cells Oncogene. ,vol. 29, pp. 978- 991 ,(2010) , 10.1038/ONC.2009.400
Kim U Birkenkamp, Leonore M L Tuyt, Chantal Lummen, Albertus T J Wierenga, Wiebe Kruijer, Edo Vellenga, The p38 MAP kinase inhibitor SB203580 enhances nuclear factor‐kappa B transcriptional activity by a non‐specific effect upon the ERK pathway British Journal of Pharmacology. ,vol. 131, pp. 99- 107 ,(2000) , 10.1038/SJ.BJP.0703534