Nighttime blood pressure and white matter hyperintensities in patients with Parkinson disease.

作者: Yoon-Sang Oh , Joong-Seok Kim , Dong-Won Yang , Ja-Seong Koo , Yeong-In Kim

DOI: 10.3109/07420528.2013.766618

关键词: EndocrinologyInternal medicineHeart rate variabilityBlood pressureNocturnalMagnetic resonance imagingCircadian rhythmHyperintensityCardiologyBrain damageHeart rateMedicine

摘要: Increasing evidence indicates that nocturnal blood pressure level and/or loss of dips are sensitive markers cardiovascular morbidity and mortality. Several studies have suggested blunted heart rate variability decline in also associated with target organ damage. These phenomena occur relatively commonly patients Parkinson disease (PD); however, few assessed the consequences these abnormalities PD. We investigated influence circadian changes on white matter hyperintensities (WMHs) The presence hypertension was increased WMH score, nighttime systolic closely related changes. Blunted were to increasing scores. non-dipping phenomenon did not WMHs. findings suggest autonomic dysfunction, particularly Therefore, it is important monitor status, because modifying regulatory disturbances can be beneficial protect against vascular brain damage

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