Degradation Mechanisms of Biodegradable Poly(DL‐lactide‐co‐glycolide)1000 Diacrylate Network as Studied by Proton Solid‐State Flow NMR Relaxometry

摘要: Degradation mechanisms of biodegradable photo-polymerised poly-(DL-lactide-co-glycolide)iooo diacrylate {[(DL-LA/GA)DA]} matrices or films were studied by proton solid-state NMR relaxometry. A flow unit cell was developed for this purpose. The (DL-LA/GA)DA-network degraded in PBS buffer solution pH =7.4. real-time method provided information about the staged break down network during continuous circulation through tube. current study shows that degradation proceeds three stages: 1 - extraction a sol fraction causes substantial immobilization material, 2 scissions chains producing defects without formation extractable products, and 3 finally, chain cause complete material. It shown [(DL-LA/GA)DA-network composed rigid viscoelastic domains on all stages degradation. This heterogeneity could be due to heterogeneous spatial distribution junctions initial and/or nano-scale phase separation polyacrylate form multifunctional poly(lactide-co-glicolide) chains. combination bulk surface erosion both nano- macroscopic scales explain observed mechanisms. is knowledge weight loss upon hydrolytic not sufficient understanding relation functional properties type hydrogels.