Metalation of arylmethyl methyl ethers and connection with their reductive electrophilic substitution
作者： Salvatore Demartis , Giovanni Melloni , Ugo Azzena , Luisa Pisano , Maria Giovanna Fiori
DOI: 10.1016/0040-4039(95)01035-G
关键词: Electrophile 、 Carbanion 、 Wittig reaction 、 Chemistry 、 Metalation 、 Electrophilic substitution 、 Organic chemistry
摘要: Abstract Stable α-methoxy arylmethyl carbanions can be generated by metalation of methyl ethers, 1 , with n -BuLi in THF at −40 °C, avoiding Wittig rearrangement to the corresponding alkoxides 2 . Reaction these various electrophiles afforded expected products 3 satisfactory yields. Connection between procedure and reductive electrophilic substitution ethers allowed transformation compounds into 2-arylpropanoic acids, 5
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sci-hub.se 参考文章(4)
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