Selective Oxytrifluoromethylation of Allylamines with CO2

摘要: Reported is the first oxy-trifluoromethylation of allylamines with carbon dioxide (CO2 ) using copper catalysis, thus leading to important CF3 -containing 2-oxazolidones. It also time CO2 , a nontoxic and easily available greenhouse gas, has been used tune difunctionalization alkenes from amino- oxy-trifluoromethylation. Of particular note, this multicomponent reaction highly chemo-, regio-, diastereoselective under redox-neutral mild conditions. Moreover, these reactions feature good functional-group tolerance, broad substrate scope, easy scalability facile product diversification. The products could be formed either spirocycles or two adjacent tetrasubstituted centers.