Vacuna para la protección de animales frente a leishmania
作者： Aseguinolaza Gloria Gonzalez , Rodríguez De Vera Vicente Emilio Larraga , Ibañez María Jesús Ramiro , Hernández Juan Antonio Castillo , Curdi Javier Lucientes
DOI:
关键词:
摘要: La presente invencion se relaciona, en general, con la prevencion de leishmaniasis animales, particular, infeccio n causada por Leishmania sp., que comprende proteina P36 infantum, o un fragmento inmunogenico misma, bien sistema expresion dicha fragmento, opcionalmente junto compuesto estimula produccion una respuesta inmune celular tipo Th1; asicomo varios protocolos vacunacion frente a sp partir del empleo vacuna.
lens.org 参考文章(5)
Gloria Gonzalez-Aseguinolaza, Soraya Taladriz, Alberto Marquet, Vicente Larraga, Molecular cloning, cell localization and binding affinity to DNA replication proteins of the p36/LACK protective antigen from Leishmania infantum FEBS Journal. ,vol. 259, pp. 909- 917 ,(2001) , 10.1046/J.1432-1327.1999.00122.X
Jack Gauldie, Claudia Raja Gabaglia, Eli E. Sercarz, Frank L. Graham, Brian Pedersen, Mary Hitt, Nicolas Burdin, Todd A. Braciak, A Single Intramuscular Injection with an Adenovirus- Expressing IL-12 Protects BALB/c Mice Against Leishmania major Infection, While Treatment with an IL-4-Expressing Vector Increases Disease Susceptibility in B10.D2 Mice Journal of Immunology. ,vol. 162, pp. 753- 760 ,(1999)
F Mattner, K Di Padova, G Alber, Interleukin-12 is indispensable for protective immunity against Leishmania major. Infection and Immunity. ,vol. 65, pp. 4378- 4383 ,(1997) , 10.1128/IAI.65.11.4378-4383.1997
Rosa María Gonzalo, Juan Ramón Rodríguez, Dolores Rodríguez, Gloria González-Aseguinolaza, Vicente Larraga, Mariano Esteban, Protective immune response against cutaneous leishmaniasis by prime/booster immunization regimens with vaccinia virus recombinants expressing Leishmania infantum p36/LACK and IL-12 in combination with purified p36. Microbes and Infection. ,vol. 3, pp. 701- 711 ,(2001) , 10.1016/S1286-4579(01)01426-5
Sanjay Gurunathan, David L. Sacks, Daniel R. Brown, Steven L. Reiner, Hughes Charest, Nicolas Glaichenhaus, Robert A. Seder, VACCINATION WITH DNA ENCODING THE IMMUNODOMINANT LACK PARASITE ANTIGEN CONFERS PROTECTIVE IMMUNITY TO MICE INFECTED WITH LEISHMANIA MAJOR Journal of Experimental Medicine. ,vol. 186, pp. 1137- 1147 ,(1997) , 10.1084/JEM.186.7.1137