Pseudo-allergic reactions to corticosteroids: diagnosis and alternatives.

摘要: Two patients treated with parenteral paramethasone (Triniol) and dexamethasone (Sedionbel) are described. A few minutes after administration of the drugs, they presented urticaria (patients 1 2) conjunctivitis (patient 1). The purpose our study was to determine cause patients' reactions, immunological mechanisms involved whether these would be able tolerate any kind corticoid. Clinical examinations skin, oral challenges different corticosteroids ELISA tests were performed. In two patients, skin negative, as prick test each its excipients. single-blind challenge Triniol positive in both ml drug, negative We also carried out other found intolerance some them. These results suggest that caused pseudoallergic reactions patients. Corticosteroids from produced hypersensitivity patients; however, a them tolerated. basic those not yet fully understood. To knowledge, this is first report pseudo-allergy by paramethasone.