1-[6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives
作者： Moon-Kook Jeon , Chang-Ho Ahn , Dong-Su Kim , Jae Yang Kong , Young-Dae Gong
DOI:
关键词: Chemistry 、 Arylpiperazine derivatives 、 Combinatorial chemistry
摘要: The present invention relates to novel quinoxaline-piperazine compounds, 1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives and their pharmaceutically acceptable salts, a process for preparation thereof, compositions containing such compounds. Therapeutic methods the treatment of hyperproliferative disorders, including cancers, by administering quinoxalin-piperazine compounds are also included.
lens.org参考文章(13)
P. Skehan, R. Storeng, D. Scudiero, A. Monks, J. McMahon, D. Vistica, J. T. Warren, H. Bokesch, S. Kenney, M. R. Boyd, New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening Journal of the National Cancer Institute. ,vol. 82, pp. 1107- 1112 ,(1990) , 10.1093/JNCI/82.13.1107
Sun-Gan Chung, Ho-Seok Kwon, Eui-Hwan Cho, Sun-Hwan Lee, Jeong-Ho Joo, Young-Hee Lee, Dong-Wook Kang, Piperazine derivatives and process for the preparation thereof ,(1997)
David A. Rowlands, Alan C. Barnes, Substituted imidazo 1,2-a-quinoxaline-4-(5H)ones, their compositions and method of use ,(1982)
I. R. AGER, A. C. BARNES, G. W. DANSWAN, P. W. HAIRSINE, D. P. KAY, P. D. KENNEWELL, S. S. MATHARU, P. MILLER, P. ROBSON, D. A. ROWLANDS, W. R. TULLY, R. WESTWOLLD, Synthesis and Oral Antiallergic Activity of Carboxylic Acids Derived from Imidazo(2,1-c)(1,4)benzoxazines, Imidazo(1,2-a)quinolines, Imidazo(1,2-a)quinoxalines, Imidazo(1,2-a)quinoxalinones, Pyrrolo(1,2-a)quinoxalinones, Pyrrolo(2,3-a ChemInform. ,vol. 19, ,(1988) , 10.1002/CHIN.198843216
Gaetan H. Ladouceur, Cheng Bi, Brian Bear, James Cook, Gang Chen, David R. Brittelli, Jacques Dumas, Michael J. Burke, Robert Sibley, Michael R. Turner, Indolyl pyrazinone derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis ,(2003)
EISAKU HAYASHI, TAKEO HIGASHINO, CHIHOKO IIJIMA, ETSUO OISHI, HIROKAZU MAKINO, TOSHIO IRIE, FUSAKO YAMAMOTO, YOKO YOKOYAMA, YOSHIHISA IWAI, HIROAKI KATO, NORIAKI SHIMADA, SENJI SUZUKI, SHIGEHISA SONE, KAZUKO MORIKAWA, HIDEO MOCHIZUKI, AKIRA MIYASHITA, TEIKO MORIKAWA, MITSUHISA IINUMA, EIKO TOMITA, MIHOKO OHKUMA, HIROTAKA SHINODA, MORIHIRO KOHNO, DENICHI MIZUNO, Anti-tumor Activity of Eighty Four Synthesized N-Heteroaromatic Compounds YAKUGAKU ZASSHI. ,vol. 97, pp. 1022- 1033 ,(1977) , 10.1248/YAKUSHI1947.97.9_1022
Peter Gruss, Luc St.-Onge, Pax6 and Pax4 nucleic acid mixtures ,(1996)
Chul Min Oh, Kyoung Ok Song, Mee Seon Park, Seong Soo Oh, Byung Hoon Yoon, Joong Young Kim, Sun Kyung Hwang, Urea derivative useful as an anti-cancer agent and process for preparing same ,(2001)
Ian R. Ager, Alan C. Barnes, Geoffrey W. Danswan, Peter W. Hairsine, David P. Kay, Peter D. Kennewell, Saroop S. Matharu, Peter Miller, Peter Robson, Synthesis and oral antiallergic activity of carboxylic acids derived from imidazo[2,1-c][1,4]benzoxazines, imidazo[1,2-a]quinolines, imidazo[1,2-a]quinoxalines, imidazo[1,2-a]quinoxalinones, pyrrolo[1,2-a]quinoxalinones, pyrrolo[2,3-a]quinoxalinones, and imidazo[2,1-b]benzothiazoles. Journal of Medicinal Chemistry. ,vol. 31, pp. 1098- 1115 ,(1988) , 10.1021/JM00401A009
Haruhiko Tomoda, Shojiro Saito, Koji Araki, Shinsaku Shiraishi, Synthesis and Physical Properties of Pyrido[1′,2′ : 1,2]imidazo[4,5-b]quinoxalines Bulletin of the Chemical Society of Japan. ,vol. 71, pp. 1125- 1135 ,(1998) , 10.1246/BCSJ.71.1125