Inhibition of lipoprotein-associated phospholipase A2 diminishes the death-inducing effects of oxidised LDL on human monocyte-macrophages.

作者: Keri L.H. Carpenter , Ian F. Dennis , Iain R. Challis , David P. Osborn , Colin H. Macphee

DOI: 10.1016/S0014-5793(01)02840-X

关键词: LipoproteinLipoprotein-associated phospholipase A2ChemistryProteaseBiochemistryCytotoxic T cellDiisopropyl fluorophosphateApoptosisLysophosphatidylcholinePhospholipase A2

摘要: … threshold concentration for pure lyso-PC. Hydrolysis of oxidised PC theoretically yields 1 mol of oxidised non-esterified fatty acid (oxNEFA) per mol of lyso-PC liberated, so oxNEFA (…

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