Intracranial olfactory neuroblastoma: evidence for olfactory epithelial origin.
作者： A K Banerjee , B S Sharma , R K Vashista , V K Kak
DOI: 10.1136/JCP.45.4.299
关键词: Intermediate filament 、 Pathology 、 Olfactory Neuroblastoma 、 Glial fibrillary acidic protein 、 Histogenesis 、 Epithelioid cell 、 Cell junction 、 Cytokeratin 、 Neuroblastoma 、 Biology
摘要: AIMS: To determine the possible histogenesis of intracranial variant olfactory neuroblastoma. METHODS: Four specimens from three cases neuroblastoma were studied by light microscopy and immuno-histochemistry, electron in two cases. RESULTS: Light microscopical examination showed small cell tumour with additional features epithelioid cells one case ganglion another. Olfactory Homer-Wright rosettes present. All a uniform positive reaction to neurone specific enolase, S-100, cytokeratin antibodies. Glial fibrillary acidic protein was absent. The salient microscopic presence junctions, cytoplasmic intermediate filaments, basal bodies cytolasmic processes. Dense cored vesicles CONCLUSIONS: results strongly support view that neuroblastomas are epithelial origin differ conventional neuroblastomas.
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