Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease

摘要: The e4 allele of the apolipoprotein E (APOE) gene is major genetic risk factor for Alzheimer’s disease (AD), but limited work has suggested that APOE genotype may modulate phenotype. Carriers have been reported to greater medial temporal lobe (MTL) pathology and poorer memory than noncarriers. Less attention focused on whether there are domains cognition neuroanatomical regions more affected in Further, a potential confound prior vivo studies possibility different rates clinical misdiagnosis carriers vs. We compared phenotypic differences topography regional cortical atrophy (n = 67) noncarriers 24) with mild AD from Disease Neuroimaging Initiative, restricted those cerebrospinal fluid (CSF) molecular profile consistent AD. Between-group comparisons were made psychometric tests morphometric measures thickness hippocampal volume. displayed significantly impairment retention, whereas impaired working memory, executive control, lexical access. Consistent this cognitive dissociation, exhibited MTL atrophy, had frontoparietal atrophy. Performance deficits particular associated disproportionate brain within nodes networks thought subserve these processes. These convergent neuroanatomic findings individuals CSF support hypothesis modulates phenotype through influence specific large-scale networks.