Endothelin-1 rs9296344 associates with the susceptibility of childhood primary nephrotic syndrome.
作者： Ruifeng Zhang , Huandan Yang , Bingbing Zhu , Tingting Yuan , Qianqian Peng
DOI: 10.1002/JCLA.23134
关键词: Logistic regression 、 Single-nucleotide polymorphism 、 SNP 、 Allele 、 Confidence interval 、 Nephrotic syndrome 、 Oncology 、 Medicine 、 Risk factor 、 Internal medicine 、 Odds ratio
摘要: Background Recently, the rs5370 single nucleotide polymorphisms (SNPs) of Endothelin-1 (EDN1) showed association with susceptibility childhood primary nephrotic syndrome (CPNS). This study aims to investigate potential relationships between other EDN1 SNPs and CPNS. Methods Seven (rs5370, rs10478723, rs1476046, rs1800541, rs2070698, rs2071942, rs9296344) gene were genotyped in 579 CPNS patients 586 age-matched healthy children. Then, we analyzed associations six by using as a conditional variant logistic regression model. SNP-SNP interaction analysis was performed joint effects seven pathogenesis Results Independent rs5370, only rs9296344 significantly associated (T vs C, odds ratio [OR] = 0.71, 95% confidence interval [CI] 0.57-0.88, P .001) Meanwhile, no effect among discovered this study. Conclusions that C allele on is novel independent risk factor for
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