Combination therapies using metformin and/or valproic acid in prostate cancer: Possible mechanistic interactions
作者： Linh N.K. Tran , Ganessan Kichenadasse , Pamela J. Sykes
DOI: 10.2174/1568009618666180724111604
关键词: Medicine 、 Cancer 、 Cancer research 、 Prostate cancer 、 PTEN 、 Androgen receptor 、 Fusion gene 、 Histone deacetylase inhibitor 、 Valproic Acid 、 Metformin
摘要: Prostate cancer (PCa) is the most frequent in men. The evolution from local PCa to castration-resistant PCa, an end-stage of disease, often associated with changes genes such as p53, androgen receptor, PTEN, and ETS gene fusion products. Evidence accumulating that repurposing metformin (MET) valproic acid (VPA) either when used alone, or combination, another therapy, could potentially play a role slowing down progression. This review provides overview application MET VPA, both alone combination other drugs for treatment, correlates responses these common molecular then describes potential combined VPA systemic therapy prostate cancer, based on interacting mechanisms.
eurekaselect.com
flinders.edu.au参考文章(148)
Soha Salama El Sheikh, Hanna M. Romanska, Paul Abel, Jan Domin, El-Nasir Lalani, Predictive value of PTEN and AR coexpression of sustained responsiveness to hormonal therapy in prostate cancer--a pilot study. Neoplasia. ,vol. 10, pp. 949- 953 ,(2008) , 10.1593/NEO.08582
Dhundy R. Bastola, Gurcharan S. Pahwa, Ming‐Fong Lin, Pi‐Wan Cheng, Downregulation of PTEN/MMAC/TEP1 expression in human prostate cancer cell line DU145 by growth stimuli. Molecular and Cellular Biochemistry. ,vol. 236, pp. 75- 81 ,(2002) , 10.1023/A:1016191913274
Jenny P. Nobes, Stephen E.M. Langley, Tanya Klopper, David Russell-Jones, Robert W. Laing, A prospective, randomized pilot study evaluating the effects of metformin and lifestyle intervention on patients with prostate cancer receiving androgen deprivation therapy BJUI. ,vol. 109, pp. 1495- 1502 ,(2012) , 10.1111/J.1464-410X.2011.10555.X
Wang Chen-Pin, John R Downs, Donna Lehman, Carlos Lorenzo, Ian M Thompson, Bradley Pollock, Hernandez Javier, Statins and Finasteride Use Differentially Modify the Impact of Metformin on Prostate Cancer Incidence in Men with Type 2 Diabetes Annals of Translational Medicine. ,vol. 1, ,(2014)
Aykut Üren, Said Rahim, Emergence of ETS transcription factors as diagnostic tools and therapeutic targets in prostate cancer. American Journal of Translational Research. ,vol. 5, pp. 254- 268 ,(2013)
Dan Robinson, Eliezer M Van Allen, Yi-Mi Wu, Nikolaus Schultz, Robert J Lonigro, Juan-Miguel Mosquera, Bruce Montgomery, Mary-Ellen Taplin, Colin C Pritchard, Gerhardt Attard, Himisha Beltran, Wassim Abida, Robert K Bradley, Jake Vinson, Xuhong Cao, Pankaj Vats, Lakshmi P Kunju, Maha Hussain, Felix Y Feng, Scott A Tomlins, Kathleen A Cooney, David C Smith, Christine Brennan, Javed Siddiqui, Rohit Mehra, Yu Chen, Dana E Rathkopf, Michael J Morris, Stephen B Solomon, Jeremy C Durack, Victor E Reuter, Anuradha Gopalan, Jianjiong Gao, Massimo Loda, Rosina T Lis, Michaela Bowden, Stephen P Balk, Glenn Gaviola, Carrie Sougnez, Manaswi Gupta, Y Yu Evan, Elahe A Mostaghel, Heather H Cheng, Hyojeong Mulcahy, Lawrence D True, Stephen R Plymate, Heidi Dvinge, Roberta Ferraldeschi, Penny Flohr, Susana Miranda, Zafeiris Zafeiriou, Nina Tunariu, Joaquin Mateo, Raquel Perez-Lopez, Francesca Demichelis, Brian D Robinson, Marc Schiffman, David M Nanus, Scott T Tagawa, Alexandros Sigaras, Kenneth W Eng, Olivier Elemento, Andrea Sboner, Elisabeth I Heath, Howard I Scher, Kenneth J Pienta, Philip Kantoff, Johann S De Bono, Mark A Rubin, Peter S Nelson, Levi A Garraway, Charles L Sawyers, Arul M Chinnaiyan, None, Integrative clinical genomics of advanced prostate cancer Cell. ,vol. 161, pp. 1215- 1228 ,(2015) , 10.1016/J.CELL.2015.05.001
Jerry E Chipuk, Tomomi Kuwana, Lisa Bouchier-Hayes, Nathalie M Droin, Donald D Newmeyer, Martin Schuler, Douglas R Green, None, Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. ,vol. 303, pp. 1010- 1014 ,(2004) , 10.1126/SCIENCE.1092734
Louise B. Grochow, Mario A. Eisenberger, Victoria Sinibaldi, Yelena Zabelina, M. Katherine Bowling, Dennis Noe, Jill Gilbert, Michael A. Carducci, Ross C. Donehower, Tian-ling Chen, A Phase I Clinical and Pharmacological Evaluation of Sodium Phenylbutyrate on an 120-h Infusion Schedule Clinical Cancer Research. ,vol. 7, pp. 3047- 3055 ,(2001)
Jorge A. Almenara, Roberto R. Rosato, Steven Grant, The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1. Cancer Research. ,vol. 63, pp. 3637- 3645 ,(2003)
Paul Waring, Arno Müllbacher, Cell death induced by the Fas/Fas ligand pathway and its role in pathology. Immunology and Cell Biology. ,vol. 77, pp. 312- 317 ,(1999) , 10.1046/J.1440-1711.1999.00837.X