AIDS dementia complex and HIV-1 brain infection: a pathogenetic framework for treatment and evaluation.

摘要: This review focuses on three aspects of prevention and treatment the AIDS dementia complex (ADC) central nervous system (CNS) human immunodeficiency virus type one (HIV-1) infection: (1) a pathogenetic framework for classification development therapies, (2) derivative therapeutic strategies (3) evaluation methodologies. While preventing initial exposure systemic HIV-1 infection is clearly most important approach to eliminating morbidity mortality its diverse manifestations, this considers only approaches neurologically symptomatic patients neurological diseases in those already infected, so called secondary prophylaxis.