Perioperative and Maintenance Therapy After First-Line Therapy as Paradigms for Drug Discovery in Urothelial Carcinoma.

摘要: Perioperative chemotherapy provided to increase the chance of cure for localized disease and maintenance therapy metastatic represent 2 distinct aspects urothelial cancer treatment spectrum. The ability access both pre- postchemotherapy tissue in neoadjuvant setting provides important opportunities translational research test novel therapies identify predictors response therapy. may be more complex, study design endpoints need determined on basis candidate drugs' mechanisms action toxicity.