Mitochondria-Targeted Protective Compounds in Parkinson's and Alzheimer's Diseases.

摘要: Mitochondria are cytoplasmic organelles that regulate both metabolic and apoptotic signaling pathways; their most highlighted functions include cellular energy generation in the form of adenosine triphosphate (ATP), regulation calcium homeostasis, balance between ROS production detoxification, mediation apoptosis cell death, synthesis metabolism various key molecules. Consistent evidence suggests mitochondrial failure is associated with early events pathogenesis ageing-related neurodegenerative disorders including Parkinson’s disease Alzheimer’s disease. Mitochondria-targeted protective compounds prevent or minimize dysfunction constitute potential therapeutic strategies prevention treatment these central nervous system diseases. This paper provides an overview involvement diseases, particular attention to vitro vivo studies on promising endogenous exogenous mitochondria-targeted compounds.