Evidence for a direct antitumor mechanism of action of bovine lactoferricin.

摘要: Background Bovine lactoferrin (LFB) and its pepsin-generated peptide lactoferricin (LfcinB) possess antitumor activities. The mechanism underlying the activities of LfcinB in vivo has not been elucidated. In this study exerted by LFB, murine (LfcinM) on tumor cell lines experimental tumors were investigated. MATEIALS AND METHODS: protein peptides tested against Meth A fibrosarcoma, B16F10 melanoma C26 colon carcinoma cells vitro their derived vivo, exploring mechanisms activity way histological scanning electron microscopical studies. Results significant cytotoxic three significantly reduced size solid tumors. Scanning micrographs revealed membrane disruption eventually lysis, while extensive hemorrhagic necrosis was apparent sections one day after treatment. No species-specific effect LfcinM observed. Conclusion Our demonstrated that elicits an mediated through a direct action observed with LFB or LfcinM.