Preparation and characterization of biomorphic poly(l-lactide-co-β-malic acid) scaffolds
作者： Junmin Qian , Weijun Xu , Wei Zhang , Xinxia Jin
DOI: 10.1016/J.MATLET.2014.03.109
关键词: Biocompatibility 、 Hydrogenolysis 、 Lactide 、 Copolymer 、 Chemical engineering 、 Polymer chemistry 、 Morphology (linguistics) 、 Materials science 、 Polymerization 、 Glass transition 、 Chemical structure
摘要: Abstract In this study, poly( l -lactide-co-β-malic acid) (PLMA) copolymer was synthesized via ring-opening polymerization of -lactide and β-benzyloxycarbonyl-β-propiolactone, followed by removal benzyl protective groups through hydrogenolysis. Novel biomorphic PLMA scaffolds with a honeycomb-like structure were prepared using cane as template. We investigated the chemical physicochemical properties morphology biocompatibility scaffolds. The results confirmed copolymer. amorphous had glass transition temperature 49 °C. well retained cane, porosity 85.5% compressive modulus 766.2±36.1 kPa. in vitro evaluation MC3T3-E1 cells demonstrated potential for bone tissue engineering.
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