The phosphoinositide sensitivity of the KV channel family
作者： Martin Kruse , Bertil Hille
DOI: 10.4161/CHAN.25816
关键词: Phosphatidylinositol 、 Xenopus 、 Chemistry 、 Inward-rectifier potassium ion channel 、 Voltage-gated potassium channel 、 Calcium-activated potassium channel 、 Phosphatidylinositol 4,5-bisphosphate 、 Biochemistry 、 hERG 、 Gating 、 Biophysics
摘要: Recently, we screened several KV channels for possible dependence on plasma membrane phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). The were expressed in tsA-201 cells and the PI(4,5)P2 was depleted by manipulations whole-cell experiments with parallel measurements of channel activity. In contrast to reports excised-patches using Xenopus laevis oocytes, found only KV7, but none other tested channels, be strongly dependent PI(4,5)P2. We now have extended our study KV1.2 a had not previously tested, because new published excised patches showed regulation voltage-dependence activation full agreement those results, reduction current amplitude ~20% after depletion small left shift curve channels. also KV11.1 (hERG) currents that accompanied gating shift. conclusion, whole-cel...
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