The antidepressant-like effect of the melatonin receptor ligand luzindole in mice during forced swimming requires expression of MT2 but not MT1 melatonin receptors.

摘要: We previously reported an antidepressant-like effect in C3H/HeN mice during the forced swimming test (FST) following treatment with MT 1 /MT 2 melatonin receptor ligand, luzindole. This study investigated role receptors (MT and/or ) may play of luzindole FST using a genetic deletion either (MTIKO) or KO) receptors. In light phase (ZT 9-11), (30 mg/kg, i.p.) significantly decreased immobility both wild type (WT) (135.6 ± 25.3 s, n = 7) and MTIKO (132.6 13.3 8) as compared vehicle-treated (WT: 207.1 6.0 7; KO: 209.5 6.2 (P < 0.001). dark 20-22), also time WT (89.5 13.9 KO (66.5 6.4 vehicle treated 193.8 3.5, 6; 176.6 Genetic disruption gene did not alter diurnal rhythm serum 9-11: 1.3 0.6 pg/mL, ZT 20-22: 10.3 1.1 1.4 0.7 pg/mL; 10.6 pg/mL). Swimming mice. Decreases by were affected gender age (3 months versus 8 months). contrast, decrease conclude that be mediated through blockade rather than