Reproducing asymmetrical spine shape fluctuations in a model of actin dynamics predicts self-organized criticality.

摘要: Dendritic spines change their size and shape spontaneously, but the function of this remains unclear. Here, we address in a biophysical model spine fluctuations, which reproduces experimentally measured fluctuations. For this, characterize size- fluctuations from confocal microscopy image sequences using autoregressive models new set descriptors derived circular statistics. Using model, extrapolate into longer temporal intervals find presence 1/f noise. When investigating its origins, predicts that actin dynamics underlying self-organizes critical state, creates fine balance between static filaments free monomers. In comparison against non-critical show state facilitates enlargement, happens after LTP induction. Thus, ongoing might be necessary to react quickly plasticity events.