Ancestral Asian source(s) of new world Y-chromosome founder haplotypes.

作者: T.M. Karafet , S.L. Zegura , O. Posukh , L. Osipova , A. Bergen

DOI: 10.1086/302282

关键词: GeneticsCladisticsHaplotypeFounder effectMicrosatelliteBiologyY chromosomeAllele frequencyPopulation geneticsOld World

摘要: Summary Haplotypes constructed from Y-chromosome markers were used to trace the origins of Native Americans. Our sample consisted 2,198 males 60 global populations, including 19 American and 15 indigenous North Asian groups. A set 12 biallelic polymorphisms gave rise 14 unique haplotypes that unevenly distributed among populations. Combining multiallelic variation at two Y-linked microsatellites ( DYS19 DXYS156Y ) with results in a total 95 combination haplotypes. Contra previous findings based on Y- chromosome data, our new suggest possibility more than one paternal founder haplotype. We postulate that, nine found Americans, 1C 1F are best candidates for major New World haplotypes, whereas 1B, 1I, 1U may either be and/or have arrived via recent admixture. Two other four (YAP + 4 5) probably present because post-Columbian admixture, haplotype 1G originated World, Old source final (1D) remains unresolved. The contrasting distribution patterns candidate Asia as well nested cladistic analysis, migration general region Lake Baikal Americas.

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