Long-term psychosocial consequences of hormone treatment for short stature

作者: Hanneke Visser-van Balen , Rinie Geenen , Gerdine A Kamp , Jaap Huisman , Jan M Wit

DOI: 10.1111/J.1651-2227.2007.00235.X

关键词: Small for gestational ageIdiopathic short statureShort statureMedicinePsychological adaptationPsychiatryPsychosocialPediatricsCoping (psychology)Randomized controlled trialYoung adult

摘要: Aim: To examine psychosocial functioning of young adults with idiopathic short stature or born small for gestational age after growth hormone (GH) and gonadotropin-releasing agonist (GnRHa) treatment in early adolescence no intervention. Methods: Thirty (18 treated, 12 untreated; 17–23 years; on average 5.5 years the end treatment) completed questionnaires regarding perceived competence psychological distress. They their parents were interviewed social circumstances, height-related stressors parental worries about prospects society. Results: Height gain was 2.3 cm more treated than untreated group. On none variables differences found between participants. Compared to Dutch population norms, normal. Conclusion: GH/GnRHa treatment, arrest pubertal development lower expected effects final height, is not observed lead long-term negative positive effects. Both participants go well through transition period adulthood. This suggests that, long term independent adequate adjustment case stature.

参考文章(22)
Hanneke Visser – van Balen, Rinie Geenen, Gerdine A Kamp, Jaap Huisman, Jan M Wit, Gerben Sinnema, Motives for choosing growth-enhancing hormone treatment in adolescents with idiopathic short stature: a questionnaire and structured interview study BMC Pediatrics. ,vol. 5, pp. 15- 15 ,(2005) , 10.1186/1471-2431-5-15
J.J.V. Busschbach, B. Rikken, D.E. Grobbee, F.T. De Charro, J.M. Wit, Quality of Life in Short Adults Hormone Research in Paediatrics. ,vol. 49, pp. 32- 38 ,(1998) , 10.1159/000023123
Maria Lundgren, Sven Cnattingius, Björn Jonsson, Torsten Tuvemo, Intellectual performance in young adult males born small for gestational age. Growth Hormone & Igf Research. ,vol. 14, pp. 7- 8 ,(2004) , 10.1016/J.GHIR.2004.03.004
Yvonne K. van Pareren, Hugo J. Duivenvoorden, Froukje S. M. Slijper, Hans M. Koot, Anita C. S. Hokken-Koelega, Intelligence and psychosocial functioning during long-term growth hormone therapy in children born small for gestational age. The Journal of Clinical Endocrinology and Metabolism. ,vol. 89, pp. 5295- 5302 ,(2004) , 10.1210/JC.2003-031187
E.M. Lundgren, S. Cnattingius, B. Jonsson, T. Tuvemo, Intellectual and psychological performance in males born small for gestational age. Hormone Research in Paediatrics. ,vol. 59, pp. 139- 141 ,(2003) , 10.1159/000067850
Michael B. Ranke, Towards a consensus on the definition of idiopathic short stature. Hormone Research in Paediatrics. ,vol. 45, pp. 64- 66 ,(1996) , 10.1159/000184851
Paul B. Kaplowitz, If gonadotropin-releasing hormone plus growth hormone (GH) really improves growth outcomes in short non-GH-deficient children, then what? The Journal of Clinical Endocrinology and Metabolism. ,vol. 86, pp. 2965- 2968 ,(2001) , 10.1210/JCEM.86.7.7784