Non-invasive in vitro sensing of d-glucose in pig blood
作者： Harutyun Melikyan , Emma Danielyan , Seungwan Kim , Jongchel Kim , Arsen Babajanyan
DOI: 10.1016/J.MEDENGPHY.2011.07.020
关键词: Non invasive 、 Microwave reflection 、 Materials science 、 Biochemistry 、 Microwave sensor 、 Aqueous solution 、 Microwave 、 Resonator 、 D-Glucose 、 In vitro 、 Chromatography
摘要: We have developed an electromagnetic resonant spiral sensor and measured the glycemia in pig blood concentration of D-glucose aqueous solution by using a real-time interaction phenomenon between microwave liquid. could determine glucose with minimal resolution 5 mg/dl 100-600 range at operating frequencies about 7.65 GHz (for solution) 7.77 sample). The change brings changes reflection coefficient due to resonator solution. vitro results show signal-to-noise ratio 34 dB, minimum detectible signal level 0.022 dB/(mg/dl). Our proposed system provides unique approach for non-invasive non-contact monitoring, it may serve as bloodless glucometer.
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sci-hub.se 参考文章(25)
Jongchul Kim, Arsen Babajanyan, Artur Hovsepyan, Kiejin Lee, Barry Friedman, Microwave dielectric resonator biosensor for aqueous glucose solution Review of Scientific Instruments. ,vol. 79, pp. 086107- 086107 ,(2008) , 10.1063/1.2968115
Arsen Babajanyan, Jongchul Kim, Songhui Kim, Kiejin Lee, Barry Friedman, Sodium chloride sensing by using a near-field microwave microprobe Applied Physics Letters. ,vol. 89, pp. 183504- ,(2006) , 10.1063/1.2374681
K. Fuchs, U. Kaatze, Molecular Dynamics of Carbohydrate Aqueous Solutions. Dielectric Relaxation as a Function of Glucose and Fructose Concentration Journal of Physical Chemistry B. ,vol. 105, pp. 2036- 2042 ,(2001) , 10.1021/JP0030084
S.C. Hagness, A. Taflove, J.E. Bridges, Wideband ultralow reverberation antenna for biological sensing Electronics Letters. ,vol. 33, pp. 1594- 1595 ,(1997) , 10.1049/EL:19971106
Jeffrey D. Newman, Anthony P.F. Turner, Home blood glucose biosensors: a commercial perspective Biosensors and Bioelectronics. ,vol. 20, pp. 2435- 2453 ,(2005) , 10.1016/J.BIOS.2004.11.012
Willem M. Albers, Jukka O. Lekkala, Lars Jeuken, Gerard W. Canters, Anthony P.F. Turner, Design of novel molecular wires for realizing long-distance electron transfer Bioelectrochemistry and Bioenergetics. ,vol. 42, pp. 25- 33 ,(1997) , 10.1016/S0302-4598(96)05150-1
Barry Friedman, Mariafrancis A. Gaspar, Sergey Kalachikov, Kiejin Lee, Rastislav Levicky, Gang Shen, Hyunjun Yoo, Sensitive, label-free DNA diagnostics based on near-field microwave imaging. Journal of the American Chemical Society. ,vol. 127, pp. 9666- 9667 ,(2005) , 10.1021/JA051760I
Seungwan Kim, Jongchel Kim, Arsen Babajanyan, Kiejin Lee, Barry Friedman, Noncontact characterization of glucose by a waveguide microwave probe Current Applied Physics. ,vol. 9, pp. 856- 860 ,(2009) , 10.1016/J.CAP.2008.08.007
J. C. Armour, J. Y. Lucisano, B. D. McKean, D. A. Gough, Application of Chronic Intravascular Blood Glucose Sensor in Dogs Diabetes. ,vol. 39, pp. 1519- 1526 ,(1990) , 10.2337/DIAB.39.12.1519
Kiejin Lee, Arsen Babajanyan, Chongchel Kim, Seungwhan Kim, Barry Friedman, Glucose aqueous solution sensing by a near-field microwave microprobe Sensors and Actuators A-physical. ,vol. 148, pp. 28- 32 ,(2008) , 10.1016/J.SNA.2008.06.024