Balancing prostanoid activity in the human vascular system

作者: Nicholas A. Flavahan

DOI: 10.1016/J.TIPS.2007.01.003

关键词: Context (language use)BiologyPharmacologyPlatelet activationVasoconstrictionProstacyclinPlateletInternal medicineThromboxaneProstanoidEndocrinologyCyclooxygenaseToxicology

摘要: … endothelium 3, 4. Based on this theory, COX-2 inhibitors, by selectively inhibiting endothelium-derived PGI 2 , would tip … Urinary levels of 6-keto PGF 1α have been proposed to …

参考文章(70)
Inge de Lepeleire, Marleen Depré, Kathleen Wynants, Anne van Hecken, Agnes Buntinx, Jef Arnout, Barry J. Gertz, David L. Ebel, Aimee Dallob, Peggy H. Wong, Jules I. Schwartz, Wesley Tanaka, Paul J. de Schepper, Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers. The Journal of Clinical Pharmacology. ,vol. 40, pp. 1109- 1120 ,(2000) , 10.1177/009127000004001005
Kenneth C. Lasseter, Francesca Catella-Lawson, Briggs W. Morrison, Barry J. Gertz, Shiv Kapoor, Garret A. Fitzgerald, Brendan McAdam, Dean Kujubu, Hui Quan, Lisa Antes, Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids. Journal of Pharmacology and Experimental Therapeutics. ,vol. 289, pp. 735- 741 ,(1999)
A R Brash, J A Lawson, E K Jackson, G A FitzGerald, J A Oates, C A Saggese, Metabolic disposition of prostacyclin in humans. Journal of Pharmacology and Experimental Therapeutics. ,vol. 226, pp. 78- 87 ,(1983)
P. F. Davies, Flow-mediated endothelial mechanotransduction Physiological Reviews. ,vol. 75, pp. 519- 560 ,(1995) , 10.1152/PHYSREV.1995.75.3.519
R. H. Boger, S. M. Bode-Boger, E. P. Schroder, D. Tsikas, J. C. Frolich, Increased prostacyclin production during exercise in untrained and trained men: effect of low-dose aspirin Journal of Applied Physiology. ,vol. 78, pp. 1832- 1838 ,(1995) , 10.1152/JAPPL.1995.78.5.1832
Christopher S. R. Baker, Roger J. C. Hall, Thomas J. Evans, Ariela Pomerance, Jacques Maclouf, Christophe Creminon, Magdi H. Yacoub, Julia M. Polak, Cyclooxygenase-2 Is Widely Expressed in Atherosclerotic Lesions Affecting Native and Transplanted Human Coronary Arteries and Colocalizes With Inducible Nitric Oxide Synthase and Nitrotyrosine Particularly in Macrophages Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 19, pp. 646- 655 ,(1999) , 10.1161/01.ATV.19.3.646
Xavier Norel, Laurence Walch, Jean-Pierre Gascard, Vincent de Montpreville, Charles Brink, Prostacyclin release and receptor activation: differential control of human pulmonary venous and arterial tone British Journal of Pharmacology. ,vol. 142, pp. 788- 796 ,(2004) , 10.1038/SJ.BJP.0705843
Dirk O. Stichtenoth, Verena Marhauer, Dimitrios Tsikas, Frank-Mathias Gutzki, Jurgen C. Frolich, Effects of specific COX-2-inhibition on renin release and renal and systemic prostanoid synthesis in healthy volunteers. Kidney International. ,vol. 68, pp. 2197- 2207 ,(2005) , 10.1111/J.1523-1755.2005.00676.X
Dennis J. Heavey, Susan E. Barrow, Nicola E. Hickling, James M. Ritter, Aspirin causes short-lived inhibition of bradykinin-stimulated prostacyclin production in man. Nature. ,vol. 318, pp. 186- 188 ,(1985) , 10.1038/318186A0