Epigenetic Mechanisms of Longevity and Aging.

作者: Payel Sen , Parisha P. Shah , Raffaella Nativio , Shelley L. Berger

DOI: 10.1016/J.CELL.2016.07.050

关键词: DNA methylationEpigeneticsChromatinDruggabilityEpigenesisNeuroscienceHistoneBiologyLongevityDisease

摘要: … common operative aging pathways and hallmark chromatin … pathway as discussed below) lead to a 5-fold extension in … ) and AKT, ultimately inactivating and promoting the cytoplasmic …

参考文章(186)
Heidi A. Tissenbaum, Leonard Guarente, Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans Nature. ,vol. 410, pp. 227- 230 ,(2001) , 10.1038/35065638
Kenneth Day, Lindsay L Waite, Anna Thalacker-Mercer, Andrew West, Marcas M Bamman, James D Brooks, Richard M Myers, Devin Absher, None, Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape Genome Biology. ,vol. 14, pp. 1- 19 ,(2013) , 10.1186/GB-2013-14-9-R102
Meng-Jau Lin, Lin-Ya Tang, M. Narsa Reddy, C.-K. James Shen, DNA Methyltransferase Gene dDnmt2 and Longevity of Drosophila Journal of Biological Chemistry. ,vol. 280, pp. 861- 864 ,(2005) , 10.1074/JBC.C400477200
Junhong Han, Hui Zhou, Bruce Horazdovsky, Kangling Zhang, Rui-Ming Xu, Zhiguo Zhang, Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication Science. ,vol. 315, pp. 653- 655 ,(2007) , 10.1126/SCIENCE.1133234
Jason Feser, David Truong, Chandrima Das, Joshua J. Carson, Jeffrey Kieft, Troy Harkness, Jessica K. Tyler, Elevated Histone Expression Promotes Life Span Extension Molecular Cell. ,vol. 39, pp. 724- 735 ,(2010) , 10.1016/J.MOLCEL.2010.08.015
Cathy Slack, Christian Werz, Daniela Wieser, Nazif Alic, Andrea Foley, Hugo Stocker, Dominic J. Withers, Janet M. Thornton, Ernst Hafen, Linda Partridge, Regulation of Lifespan, Metabolism, and Stress Responses by the Drosophila SH2B Protein, Lnk PLoS Genetics. ,vol. 6, pp. e1000881- ,(2010) , 10.1371/JOURNAL.PGEN.1000881
Marc Damelin, Itamar Simon, Terence I. Moy, Boris Wilson, Suzanne Komili, Paul Tempst, Frederick P. Roth, Richard A. Young, Bradley R. Cairns, Pamela A. Silver, The Genome-Wide Localization of Rsc9, a Component of the RSC Chromatin-Remodeling Complex, Changes in Response to Stress Molecular Cell. ,vol. 9, pp. 563- 573 ,(2002) , 10.1016/S1097-2765(02)00475-6
Yariv Kanfi, Shoshana Naiman, Gail Amir, Victoria Peshti, Guy Zinman, Liat Nahum, Ziv Bar-Joseph, Haim Y. Cohen, The sirtuin SIRT6 regulates lifespan in male mice Nature. ,vol. 483, pp. 218- 221 ,(2012) , 10.1038/NATURE10815
David Frescas, Luca Valenti, Domenico Accili, Nuclear Trapping of the Forkhead Transcription Factor FoxO1 via Sirt-dependent Deacetylation Promotes Expression of Glucogenetic Genes Journal of Biological Chemistry. ,vol. 280, pp. 20589- 20595 ,(2005) , 10.1074/JBC.M412357200