Chapter 8: Membrane Potential Dependence of Gap Junctions in Vertebrates
作者： Luis C. Barrio , Ana Revilla , Juan M. Goméz-Hernandez , Marta de Miguel , Daniel González
DOI: 10.1016/S0070-2161(08)61012-6
关键词: Gap junction 、 Boltzmann relation 、 Biophysics 、 Voltage dependence 、 Common method 、 Boltzmann equation 、 Membrane potential 、 Unitary conductance 、 Connexin 、 Cell biology 、 Biology
摘要: Publisher Summary The availability of cloned connexins in vertebrates, a protein family forming cell-to-cell channels, has enabled clarifying the differences among regulatory properties distinct gap junctions. To date, up to 14 isoforms have been so far rodents, and several homologs identified other species. This diversity connexin shown be functionally significant. Regulatory such as voltage dependence or pH calcium intracellular sensitivity, well single-channel properties—such their unitary conductance substates, permeability, selectivity—are specified by composition junction channels. common method used evaluate junctions is fit macroscopic junctional conductance/voltage relationship Boltzmann relation, which applies two-state system, energy difference states being linearly dependent on voltage. In most junctions, least-squares data using equation extrapolated existing provide an estimate minimum maximun steady-state, lower higher, respectively, than experimental values.
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