Changes in elderly women's health-related quality of life following discontinuation of hormone replacement therapy

摘要: Many women have discontinued hormone replacement therapy (HRT) in view of recent findings. The goal this study was to determine if HRT discontinuation is associated with changes health-related quality life (HRQOL) elderly women. We studied enrolled Pennsylvania's Pharmaceutical Assistance Contract for the Elderly (PACE) program, linking prescription claims data from a longitudinal mail survey. HRQOL measures included number days out last 30 that physical health not good and analogous mental health, pain, interference activities, as well composite "healthy days" measure developed by CDC. Longitudinal analyses focused on 2,357 who completed surveys both 2002 2003, used at baseline (mean age = 75.5, range 65–102). Propensity scores were match continuers discontinuers according type, demographics, HRQOL. Analysis covariance compare change discontinuers. Between 43% users therapy. examine revealed complex interactions age. Discontinuers aged 65–74 reported greater increases which (p < .05), fewer more interfered activities .01), pain .01). Among 75–84, .01); no other significant effects observed group. Relative continuers, 85 older experienced apparent improvements following cessation, poor These results suggest there are substantial differences response discontinuation. While declines relative improvements. among younger underscore importance communication between clinicians patients throughout process. also demonstrate value surveillance component program administration.