Aspergillus nidulans CkiA is an essential casein kinase I required for delivery of amino acid transporters to the plasma membrane
作者： Angeliki Apostolaki , Laura Harispe , Ana María Calcagno‐Pizarelli , Ioannis Vangelatos , Vicky Sophianopoulou
DOI: 10.1111/J.1365-2958.2012.08042.X
关键词: Casein kinases 、 Kinase 、 Wild type 、 Vacuole 、 Amino acid 、 Biochemistry 、 Biology 、 Aspergillus nidulans 、 Saccharomyces cerevisiae 、 Casein Kinase I
摘要: Type I casein kinases are highly conserved among Eukaryotes. Of the two Aspergillus nidulans casein kinases I, CkiA is related to the δ/ε mammalian kinases and to Saccharomyces cerevisiæ Hrr25p. CkiA is essential. Three recessive ckiA mutations leading to single residue substitutions, and downregulation using a repressible promoter, result in partial loss‐of‐function, which leads to a pleiotropic defect in amino acid utilization and resistance to toxic amino acid analogues. These phenotypes correlate with miss‐routing of …
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