Cell Competition and the Hippo Pathway

摘要: Cell competition was discovered in Drosophila as a phenomenon whereby slow growing cells are eliminated from developing tissues. Competitive cell–cell interactions can also eliminate with other defects such cell polarity. is thus regarded homeostatic mechanism that eliminates abnormal and potentially harmful cells. Notably, the elimination of by only observed mixed populations may depend on specific reciprocal interactions. However, many questions about mechanisms remain. For example, what determines competitive status how do detect differences fitness? Recent work has identified Hippo tumor suppressor pathway regulator effector Drosophila. In this chapter, we discuss linked to connection act mechanism.