Coronary flow reserve is impaired in hypertensive patients with subclinical renal damage.

摘要: BACKGROUND Renal dysfunction is relatively common in patients with primary hypertension (PH). A reduction coronary vasodilator capacity has recently been reported renal damage undergoing angiography. We investigated the relationship between flow reserve (CFR) and early abnormalities PH normal serum creatinine. METHODS Seventy-six untreated were studied. Albuminuria was measured as albumin-to-creatinine ratio glomerular filtration rate (eGFR) estimated by Cockroft-Gault formula. Chronic kidney disease (CKD) defined an eGFR <60 ml/min/1.73 m(2) and/or presence of microalbuminuria. Coronary blood velocities (cm/s) Doppler ultrasound at rest after adenosine administration. CFR hyperemic-to-resting diastolic peak velocities. RESULTS Prevalence reduced eGFR, microalbuminuria, CKD, left ventricular (LV) hypertrophy 8, 10, 16, 31%, respectively. Overall, 10% showed impaired (i.e., <2.0). Patients CKD more likely to be older (P < 0.05) female gender 0.01) higher LV mass index (LVMI) 0.05), lower 0.05; analysis covariance, P CFR/LVMI than function. Conversely, a significantly prevalence (chi(2) 5.2, microalbuminuria 10.2, 0.01), 9.2.1, 0.01). Even adjustment for gender, entailed sevenfold risk having (confidence interval 1.17-40.9, 0.05). CONCLUSION Early are associated PH.