Ameliorative Effects and Cellular Aspects of Phytoconstituents in Atherosclerosis.

摘要: Atherosclerosis is a cardiovascular disease that involves vessels through the development of fatty streaks and plaques. Plant-based compounds can help treat or prevent atherosclerosis by affecting various factors are involved in disease. The present review discusses our current knowledge major cellular molecular mechanisms phytotherapeutics for treatment atherosclerosis. Numerous studies have evaluated antiatherosclerotic activity phytoconstituents to provide preliminary evidence efficacy, but only few delineated underlying mechanisms. Plant-derived primarily targets abnormal levels lipoproteins, endothelial dysfunction, smooth muscle cell migration, foam development, atheromatous plaque formation. Nonetheless, principal responsible their therapeutic actions remain unclear. Further pharmacological needed elucidate response these phytoconstituents.