18-month outcome of clozapine treatment for 100 patients in a state psychiatric hospital.

摘要: OBJECTIVE The atypical antipsychotic medication clozapine is an effective treatment for refractory psychosis; however, the efficacy of when used in public mental health programs has yet to be fully characterized. This study assessed outcome a state hospital. METHODS medical records first 100 patients receive hospital, from six months before through 18 treatment, were reviewed. RESULTS had chronic psychotic disorders that responded poorly with conventional medication. Eighteen after beginning clozapine, 45 much improved, and somewhat improved. All except one improved continuing treatment. Forty living community settings, 59 remained hospitalized, died illness unrelated clozapine. Violent episodes hospital decreased during Thirteen or two seizures while taking 12 whom successfully continued One patient developed agranulocytosis, leucopenia; each recovered was discontinued. CONCLUSIONS Clozapine given as part routine