The influence of polysaccharides from Ophiopogon japonicus on 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-d-glucoside about biopharmaceutical properties in vitro and pharmacokinetics in vivo.
作者： Li-Li Sun , Meng Wang , Hui-Jie Zhang , Guang-jiao You , Ya-Nan Liu
DOI: 10.1016/J.IJBIOMAC.2018.07.179
关键词: Glucoside 、 Traditional medicine 、 Active ingredient 、 Ophiopogon japonicus 、 Polygonum 、 Pharmacokinetics 、 Ophiopogon 、 Chemistry 、 In vivo 、 Polysaccharide
摘要: 2,3,5,4'-Tetrahydroxy-stilbene-2-O-β-d-glucoside (THSG) is a bioactive polyhydroxystilbene compound obtained from Polygonum multiflorum Thunb. Although it has broad therapeutic potential, the application of THSG limited due to its poor stability in vitro, absorption intestine, and short-term storage tissues. Polysaccharides herbal medicines have been proven be functional foods potential natural plant derived drugs. However, effects polysaccharides when co-administered with other active ingredients are currently unknown. The present study investigated influences Ophiopogon japonicus (OJPs) on THSG. Results showed that OJPs notably enhanced aqueous solubility, THSG, but slightly decreased permeability In addition, Tmax, Cmax, AUC(0-tn) were 3.5 fold, 1.45 fold 2.32 higher for THSG-OJP. Thus, could potentially used improve biopharmaceutical properties prolong pharmacological This finding provide reference point further applications medicines.
sci-hub.se 参考文章(30)
Yunpeng Fan, Xia Ma, Lin Ma, Jing Zhang, Weimin Zhang, Xiaoping Song, Antioxidative and immunological activities of ophiopogon polysaccharide liposome from the root of Ophiopogon japonicus Carbohydrate Polymers. ,vol. 135, pp. 110- 120 ,(2016) , 10.1016/J.CARBPOL.2015.08.089
Ying-Yong Zhao, Xian-Long Cheng, Feng Wei, Xiao-Qiang Han, Xin-Yue Xiao, Rui-Chao Lin, PHARMACOKINETICS, BIOAVAILABILITY, AND METABOLISM OF 2,3,5,4′-TETRAHYDROXYSTILBENE-2-O-β-D-GLUCOSIDE IN RATS BY ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY–QUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETRY AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-ULTRAVIOLET DETECTION Journal of Liquid Chromatography & Related Technologies. ,vol. 36, pp. 717- 730 ,(2012) , 10.1080/10826076.2012.673209
R. Stone, Biochemistry. Lifting the veil on traditional Chinese medicine. Science. ,vol. 319, pp. 709- 710 ,(2008) , 10.1126/SCIENCE.319.5864.709
Youyou Tu, The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine Nature Medicine. ,vol. 17, pp. 1217- 1220 ,(2011) , 10.1038/NM.2471
Yizhong Cai, Qiong Luo, Mei Sun, Harold Corke, Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sciences. ,vol. 74, pp. 2157- 2184 ,(2004) , 10.1016/J.LFS.2003.09.047
H. Hatcher, R. Planalp, J. Cho, F. M. Torti, S. V. Torti, Curcumin: From ancient medicine to current clinical trials Cellular and Molecular Life Sciences. ,vol. 65, pp. 1631- 1652 ,(2008) , 10.1007/S00018-008-7452-4
Sophia Y. K. Fong, Mary Liu, Hai Wei, Raimar Löbenberg, Isadore Kanfer, Vincent H. L. Lee, Gordon L. Amidon, Zhong Zuo, Establishing the pharmaceutical quality of Chinese herbal medicine: a provisional BCS classification. Molecular Pharmaceutics. ,vol. 10, pp. 1623- 1643 ,(2013) , 10.1021/MP300502M
Xiaoming Chen, Jia Tang, Wenyuan Xie, Junjun Wang, Jing Jin, Jun Ren, Liqin Jin, Jianxin Lu, Protective effect of the polysaccharide from Ophiopogon japonicus on streptozotocin-induced diabetic rats. Carbohydrate Polymers. ,vol. 94, pp. 378- 385 ,(2013) , 10.1016/J.CARBPOL.2013.01.037
Hewei Li, Ling Dong, Yang Liu, Guopeng Wang, Gang Wang, Yanjiang Qiao, None, Biopharmaceutics classification of puerarin and comparison of perfusion approaches in rats International Journal of Pharmaceutics. ,vol. 466, pp. 133- 138 ,(2014) , 10.1016/J.IJPHARM.2014.03.014
Qing Zhang, Yi Xu, Sheng Zou, Xiaodan Zhang, Kun Cao, Qi Fan, Novel functional polysaccharides from Radix Polygoni Multiflori water extracted residue: Preliminary characterization and immunomodulatory activity. Carbohydrate Polymers. ,vol. 137, pp. 625- 631 ,(2016) , 10.1016/J.CARBPOL.2015.11.023