Acute and sub-chronic toxicity study of diaveridine in Wistar rats

摘要: Abstract Diaveridine, a developed dihydrofolate reductase inhibitor, has been widely used as anticoccidial drug and antibacterial synergist. However, few studies have performed to investigate its toxicity. To provide detailed toxicity with wide spectrum of doses for diaveridine, acute sub-chronic were conducted. Calculated LD 50 was 2330 mg/kg b.w. in females 3100 mg/kg males, chromodacryorrhea noted some before their death. In the study, diaveridine fed Wistar rats during 90 days at dietary levels 0, 23, 230, 1150 2000 mg/kg, which about 2.0–2.3, 21.0–23.5, 115.2–126.9 212.4–217.9 mg/kg b.w., respectively. Significant decrease body weights both genders 2000 mg/kg groups significant increases relative brain genders, liver females, kidneys testis alkaline phosphatase potassium diet noted. absolute several organs, hemoglobin red blood cell count albumin total protein observed diet. Fibroblasts kidneys, swelling glomerular zone adrenals inflammation found group. The no-observed-adverse-effect level 230 mg/kg (21.0–23.5 mg/kg b.w./day).