Components to the acid-base related ventilatory drives in the South American lungfish Lepidosiren paradoxa.
作者： J. Amin-Naves , H. Giusti , A. Hoffmann , M.L. Glass
DOI: 10.1016/J.RESP.2006.03.003
关键词: Endocrinology 、 South American lungfish 、 Central chemoreceptors 、 Lungfish 、 Hypercarbia 、 Biology 、 Anesthesia 、 Respiratory system 、 Internal medicine 、 Peripheral chemoreceptors 、 Respiration 、 Breathing
摘要: Lungfish are closely related to terrestrial vertebrates (tetrapoda). Like tetrapods, the South American lungfish (Lepidosiren paradoxa) has central chemoreceptors involved in regulation of acid-base status. However, no data were available on peripheral CO(2)/[H(+)] receptors. Therefore, we tested hypothesis that such receptors exist by measuring ventilatory responses during a 5h exposure combined aquatic/gas phase hypercarbia 7% (approximately 49 mmHg). Normocarbic control ventilation was 22 ml BTPS kg(-1)h(-1), and increased 175 kg(-1)h(-1) at 5h. This procedure repeated with modification normocarbic mock CSF (pH 7.45; P(CO2) = 20.7 mmHg) applied superfuse cerebral ventricular system last 2h experiment. served eliminate hypercarbic stimulus chemoreceptors, while possible from would remain intact. Peripheral detected, since became reduced 62 (P<0.05), which exceeds initial (P<0.05). Based this, contribution accounted for 20% total response hypercarbia, similar these man.
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