Long-range intercellular Ca2+ wave patterns

摘要: Modulational instability is utilized to investigate intercellular Ca2+ wave propagation in an array of diffusively coupled cells. Cells are supposed be connected via paracrine signaling, where long-range effects, due the presence extracellular messengers, included. The multiple-scale expansion used show that whole dynamics waves, from endoplasmic reticulum cytosol, can reduced a single differential-difference nonlinear equation whose solutions assumed plane waves. Their linear stability analysis studied, with emphasis on impact coupling, range parameter s. It shown s, as well number interacting cells, importantly modifies features modulational instability, small values s imply strong and increasing its value rather reduces problem first-neighbor one. Our theoretical findings numerically tested, generic equations fully integrated, leading emergence patterns Strong coupling pictured by extended trains breather-like structures frequency decreases We also cells plays spatio-temporal formation patterns, whilst quasi-perfect communication depends parameter.