Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

摘要: Canine hemangiosarcoma is a highly aggressive vascular neoplasm associated with extensive clinical and anatomical heterogeneity grave prognosis. Comprehensive molecular characterization of may identify novel therapeutic targets advanced management strategies, but there are no published reports tumor-associated genome instability disrupted gene dosage in this cancer. We performed genome-wide microarray-based somatic DNA copy number profiling 75 primary intra-abdominal hemangiosarcomas from five popular dog breeds that predisposed to disease. The cohort exhibited limited global genomic instability, compared other canine sarcomas studied date, aberrations (CNAs) were predominantly low amplitude. Recurrent imbalances several key cancer-associated genes evident; however, the penetrance any single CNA was distinct hallmark evident. Copy gains chromosomes 13, 24, 31, loss chromosome 16, most recurrent CNAs involving large regions, their relative distribution within between cases suggests they likely represent passenger aberrations. CDKN2A, VEGFA, SKI oncogene identified as potential driver development, highlighting for modulation. profiles broadly conserved breeds, although subregional variation evident, including near twofold lower incidence VEGFA gain Golden Retrievers versus (22 40 %). These observations support prior transcriptional studies suggesting cancer reflect existence multiple, molecularly subtypes hemangiosarcoma.