Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

作者: Y. Zhang , H.-H. Ng , H. Erdjument-Bromage , P. Tempst , A. Bird

DOI: 10.1101/GAD.13.15.1924

关键词: BiochemistryHDAC11Histone octamerMi-2/NuRD complexHistone deacetylase 5Histone codeHistone deacetylase activityHistone deacetylase 2BiologyHistone deacetylase complex

摘要: … To gain insight into the function of the NuRD complex, we have identified its p70 and p32 … of NuRD. Furthermore, we provide evidence linking NuRD function to methylated DNA. …

参考文章(67)
Peter L. Jones, Gert Jan C. Veenstra, Paul A. Wade, Danielle Vermaak, Stefan U. Kass, Nicoletta Landsberger, John Strouboulis, Alan P. Wolffe, Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nature Genetics. ,vol. 19, pp. 187- 191 ,(1998) , 10.1038/561
Francesco Grignani, Silvia De Matteis, Clara Nervi, Lucia Tomassoni, Vania Gelmetti, Mario Cioce, Mirco Fanelli, Marthin Ruthardt, Fabiana F. Ferrara, Iris Zamir, Christian Seiser, Fausto Grignani, Mitchell A. Lazar, Saverio Minucci, Pier Giuseppe Pelicci, Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. Nature. ,vol. 391, pp. 815- 818 ,(1998) , 10.1038/35901
Michael Grunstein, Histone acetylation in chromatin structure and transcription Nature. ,vol. 389, pp. 349- 352 ,(1997) , 10.1038/38664
Jeffrey K. Tong, Christian A. Hassig, Gavin R. Schnitzler, Robert E. Kingston, Stuart L. Schreiber, Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex Nature. ,vol. 395, pp. 917- 921 ,(1998) , 10.1038/27699
Richard J. Lin, Laszlo Nagy, Satoshi Inoue, Wenlin Shao, Wilson H. Miller, Ronald M. Evans, Role of the histone deacetylase complex in acute promyelocytic leukaemia Nature. ,vol. 391, pp. 811- 814 ,(1998) , 10.1038/35895
Sanjoy K. Bhattacharya, Shyam Ramchandani, Nadia Cervoni, Moshe Szyf, A mammalian protein with specific demethylase activity for mCpG DNA Nature. ,vol. 397, pp. 579- 583 ,(1999) , 10.1038/17533
Stephen E. Rundlett, Andrew A. Carmen, Noriyuki Suka, Bryan M. Turner, Michael Grunstein, Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3. Nature. ,vol. 392, pp. 831- 835 ,(1998) , 10.1038/33952
Alexander Brehm, Eric A. Miska, Dennis J. McCance, Juliet L. Reid, Andrew J. Bannister, Tony Kouzarides, Retinoblastoma protein recruits histone deacetylase to repress transcription Nature. ,vol. 391, pp. 597- 601 ,(1998) , 10.1038/35404