Disabling neurological complications of amiodarone.
作者： N. E. ANDERSON , N. M. LYNCH , K. P. O'BRIEN
DOI: 10.1111/J.1445-5994.1985.TB04040.X
关键词: Anesthesia 、 Medicine 、 Amiodarone 、 Gait Ataxia 、 Myopathy 、 Drug withdrawal 、 Maintenance dose 、 Polyneuropathy
摘要: : Five patients developed neurological symptoms during treatment with amiodarone for intervals ranging between five and 40 months. In each case the daily maintenance dose did not exceed 600 mg. The manifestations included gait ataxia, tremor, polyneuropathy, myopathy. all patients, were severe disabling. one patient a myopathy, there was no improvement after withdrawn. side effects of may be disabling are always reversible drug withdrawal. Neurological complications arise usual doses. (Aust NZ J Med 1985; 15: 300–304.)
sci-hub.se 参考文章(10)
F. Lustman, G. Monseu, AMIODARONE AND NEUROLOGICAL SIDE-EFFECTS The Lancet. ,vol. 303, pp. 568- ,(1974) , 10.1016/S0140-6736(74)92757-3
Frank I Marcus Fontain, Guy H, Robert Frank, Yves Grosgogeat, Clinical pharmacology and therapeutic applications of the antiarrhythmic agent amiodarone. American Heart Journal. ,vol. 101, pp. 480- 493 ,(1981) , 10.1016/0002-8703(81)90140-X
B McGovern, H Garan, E Kelly, J N Ruskin, Adverse reactions during treatment with amiodarone hydrochloride. BMJ. ,vol. 287, pp. 175- 180 ,(1983) , 10.1136/BMJ.287.6386.175
Charles I Haffajee, John C Love, Joseph S Alpert, George K Asdourian, Kathy C Sloan, Efficacy and safety of long-term amiodarone in treatment of cardiac arrhythmias: Dosage experience American Heart Journal. ,vol. 106, pp. 935- 943 ,(1983) , 10.1016/0002-8703(83)90019-4
J. A. JOHNS, J. FEDERMAN, R. W. HARPER, S. T. ANDERSON, P. J. CURRIE, A. PITT, Amiodarone therapy for life threatening or refractory cardiac arrhythmias. Australian and New Zealand Journal of Medicine. ,vol. 13, pp. 248- 256 ,(1983) , 10.1111/J.1445-5994.1983.TB04652.X
L Harris, W J McKenna, E Rowland, D W Holt, G C Storey, D M Krikler, Side effects of long-term amiodarone therapy. Circulation. ,vol. 67, pp. 45- 51 ,(1983) , 10.1161/01.CIR.67.1.45
J.F. Lemaire, A. Autret, K. Biziere, J.L. Romet-Lemone, F. Gray, Amiodaron neuropathy: further arguments for human drug-induced neurolipidosis. European Neurology. ,vol. 21, pp. 65- 68 ,(1982) , 10.1159/000115456
M. E. Charness, F. Morady, M. M. Scheinman, Frequent neurologic toxicity associated with amiodarone therapy Neurology. ,vol. 34, pp. 669- 669 ,(1984) , 10.1212/WNL.34.5.669
S M Sobol, L Rakita, Pneumonitis and pulmonary fibrosis associated with amiodarone treatment: a possible complication of a new antiarrhythmic drug. Circulation. ,vol. 65, pp. 819- 824 ,(1982) , 10.1161/01.CIR.65.4.819
C. Meier, B. Kauer, U. M�ller, H. P. Ludin, Neuromyopathy during chronic amiodarone treatment. A case report. Journal of Neurology. ,vol. 220, pp. 231- 239 ,(1979) , 10.1007/BF00314147