Transporters and drug discovery: why, when, and how.

摘要: Drug transporters are now increasingly recognized as important determinants of variable drug disposition and response. In addition, transporter associated problems appear to be occurring with greater frequency during the discovery development process. What has not been clear is whether related issues a truly new problem, or such had existed all along, but were previously unrecognized ignored. this review, brief overview key will outlined. commentary on specific relevance pharmaceutical sciences in terms role process provided. Keywords: transport; P-glycoprotein; pharmacokinetics;