Autistic children exhibit distinct plasma amino acid profile.

摘要: In order to ascertain whether autistic children display characteristic metabolic signatures that are of diagnostic value, plasma amino acid analyses were carried out on a cohort 138 and normal controls using reverse-phase HPLC. Pre-column derivatization acids with phenyl isothiocyanate forms thio-carbamate derivates have lamba(max) 254 nm, enabling their detection photodiode array. Autistic showed elevated levels glutamic (120 +/- 89 vs. 83 35 micromol/L) asparagine (85 37 47 19 micromol/L); lower phenylalanine (45 20 59 18 micromol/L), tryptophan (24 11 41 16 methionine (22 9 28 histidine 21 58 15 micromol/L). A low molar ratio (tryptophan/large neutral acids) x 100 was observed in autism (5.4 vs 9.2), indicating lesser availability for neurotransmitter serotonin synthesis. To conclude, excitatory (glutamate asparagine), decreased essential (phenylalanine, methionine) precursors neurotransmitters (tyrosine tryptophan) the distinct characteristics profile children. Thus, such might be useful tools early diagnosis autism.