Spontaneous abortions among women working in the pharmaceutical industry.

摘要: A register based study was conducted on the pregnancy outcome of female workers in eight Finnish pharmaceutical factories to determine whether they had a higher risk spontaneous abortion than general population or matched controls. Information about all who been employed during years 1973 1975 (four factories) 1980 obtained from employers. The workers' data were collected nation wide hospital discharge and polyclinic hospitals 1981. total number 1795 pregnancies included 1179 deliveries, 142 abortions, 474 induced abortions. rate (the abortions X 100, divided by plus births) employment 10.9% before/after 10.6%. for women corresponding central districts 11.3% [corrected] period. case-control also carried out which cases 44 factory. Three age factory given birth child chosen as controls every case. information occupational exposures questionnaires completed physician nurse at response 93%. Exposure chemicals more common among For methylene chloride, solvent commonly used industry, increase odds ratio borderline significance (odds 2.3, p = 0.06). In logistic regression model (which oestrogen exposure, exposure frequency usage, heavy lifting) increased oestrogens 4.2, 0.05) continuous lifting 5.7, 0.02). greater those exposed four solvents 3.5, p=0.05) one three ration 0.8, p=0.74).