Towards prediction of cognate complexes between the WW domain and proline‐rich ligands

摘要: The WW domain is a structured protein module found in wide range of regulatory, cytoskeletal, and signaling molecules. Its ligands contain proline-rich sequences, some which show core consensus XPPXY that critical for binding. In order to gain better understanding the molecular biological functions domains, we decided predict their cognate by searching databases proteins containing consensus. Using several axioms take into account evolutionary conservation functional similarity, have identified four groups representing candidate signal through known or unknown domains. These include viral Gag proteins, sodium channels, interleukin receptors, subgroup serine/threonine kinases. addition, proposed dystrophin β-dystroglycan bind WW-XPPXY link interference with this interaction could result muscular dystrophy. Our study provides guidelines experiments probe domain-ligand connection. Should these predictions be proven empirically, results may important ramifications basic research medicine.