Perioperative Synbiotics Decrease Postoperative Complications in Periampullary Neoplasms: A Randomized, Double-Blind Clinical Trial

摘要: Periampullary neoplasms are rapidly progressive tumors with a poor prognosis and high morbidity mortality rates, which have negative influence on patient outcomes. Some probiotics prebiotics the ability to protect intestinal barrier prevent bacterial translocation, infection, postoperative complications. We evaluated use of synbiotics in prospective, double-blind study patients undergoing surgery for periampullary (PNs) assessed effect these agents nutritional status, complications, antibiotic use, length hospital stay, mortality. Patients were randomized receive prebiotics-synbiotics--group S [Lactobacillus acidophilus 10, 1 × 10(9)CFU, Lactobacillus rhamnosus HS 111, 10(9) CFU, casei Bifidobacterium bifidum, fructooligosaccharides (FOS) 100 mg]--or placebo-controls--group C, twice daily, total 14 days. Risk, clinical complication rates assessed. Twenty-three allocated each group. The incidence infection was significantly lower group (6 23 patients, 26.1%) than C (16 69.6%) (P = 0.00). Duration therapy also shorter (mean 9 days vs. 15 C; P 0.01). Noninfectious complications less common 0.03). Mean stay 12 ± 5 No deaths occurred S, whereas 6 0.02). Perioperative administration reduces PNs.