Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016.

摘要: Tumor budding is a well-established independent prognostic factor in colorectal cancer but standardized method for its assessment has been lacking. The primary aim of the International Budding Consensus Conference (ITBCC) was to reach agreement on an international, evidence-based scoring system tumor cancer. ITBCC included nine sessions with presentations, pre-meeting survey and e-book covering key publications 'Grading Recommendation Assessment, Development Evaluation' used determine strength recommendations quality evidence. following 10 statements achieved consensus: defined as single cell or cluster consisting four cells less (22/22, 100%). predictor lymph node metastases pT1 (23/23, survival stage II should be taken into account along other clinicopathological features multidisciplinary setting counted H&E (19/22, 86%). Intratumoral exists shown related metastasis assessed one hotspot (in field measuring 0.785 mm2) at invasive front A three-tier count order facilitate risk stratification grade are not same guidelines/protocols reporting Members were able strong consensus reporting. It proposed that this incorporated staging systems.