Fluticasone Induces Epithelial Injury and Alters Barrier Function in Normal Subjects.

摘要: Objective: The airway epithelium has a number of roles pivotal to the pathogenesis asthma, including provision physical and immune barrier inhaled environment. Dysregulated injury repair responses in asthma result loss epithelial integrity. Inhaled corticosteroids are corner stone treatment. While effective controlling symptoms, they fail prevent remodeling. Direct cytopathic effects on may contribute this. Methods: This study examined 4-week treatment regimen fluticasone 500 μg twice daily healthy human subjects. Induced sputum was collected for cell counts markers inflammation. Barrier function by diethylenetriaminepentacetic acid (DTPA) clearance measured nuclear scintillation scan, albumin concentration induced sputum. Results: Steroid exposure resulted as significant increase cells sputum. There no change inflammation inflammatory or cytokine levels. Epithelial shedding associated with an function, both decrease DTPA decreased likely reflects normal response. Conclusion: cause epithelium. These warrant further evaluation where dysregulated response