The ABCC2 c.-24C > T polymorphism increases the risk of resistance to antiepileptic drugs: A meta-analysis

摘要: Several studies examined a possible link between multidrug resistance-associated protein 2 (ABCC2) gene variants and the risk of resistance to antiepileptic drugs (AEDs) in epilepsy, but results were contradictory. In this study, meta-analysis was conducted assess relevance ABCC2 common (c.-24C>T, c.1249G>A, c.3972C>T) with response AEDs. We searched Embase, PubMed, Cochrane Library CNKI databases for case-control published through May 2016 that evaluated role pharmacoresistance Odds ratios (ORs) their 95% confidence intervals (CIs) calculated strength associations c.-24C>T, c.1249G>A c.3972C>T AEDs using an allele frequency model, dominant model recessive model. Subgroup analyses performed by ethnicity definition drug-resistance. A total 13 involving 4300 patients (2261 drug-resistant epilepsy 2039 controls drug-responsive epilepsy) met selection criteria. observed variant c.-24C>T associated significantly increased AED (TT+CT vs CC: OR=1.24, 95%CI=1.06-1.46, p=0.009; TT CT+CC: OR=1.90, 95%CI=1.31-2.76, p=0.0008; T C: OR=1.27, 95%CI=1.11-1.46, p=0.0006). However, we identified no significant association haplotypes anticonvulsant drug overall population. summary, these observations suggest polymorphism is likely factor