The concept of axial spondyloarthritis. Lessons from the INFAST study
作者： Henning Zeidler
DOI: 10.1136/ANNRHEUMDIS-2013-204940
关键词: Naproxen 、 Clinical trial 、 Axial spondyloarthritis 、 Refractory 、 Combination therapy 、 Internal medicine 、 Infliximab 、 Antirheumatic Agents 、 Antagonist 、 Surgery 、 Medicine
摘要: Sieper et al 1 evaluated whether combination therapy with infliximab (IFX) and naproxen (NPX) was superior to treatment NPX alone in patients who had active moderate-to-severe early (disease duration under 3 years) axial spondyloarthritis (SpA) were naive non-steroidal anti-inflammatory drugs (NSAIDs) or only been treated a submaximal dose of NSAIDs. This study is the first investigation potential benefits tumour necrosis factor (TNF) antagonist SpA are not yet refractory NSAID therapy. Additionally, this represents randomised controlled clinical trial use imaging portion Assessment SpondyloArthritis International Society criteria for inflammation sacroiliac joints on MRI at baseline. Most importantly, …
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