Regulation of Lipid Metabolism by Cyclic Nucleotides
作者： J. N. Fain
DOI: 10.1007/978-3-642-68393-0_2
关键词: Cyclase 、 Adenylate kinase 、 Protein kinase A 、 Chemistry 、 Adenosine 、 Cholera toxin 、 Cyclic nucleotide 、 Biochemistry 、 Lipolysis 、 Cyclase activity
摘要: The intracellular concentration of cyclic AMP regulates triglyceride breakdown in adipocytes. However, it remains to be established whether hormones which activate lipolysis exert their effects solely through AMP. Under appropriate conditions, all agents increase adipocytes formation. Catecholamines and other activators adipocyte also the activity adenylate cyclase, protein kinase triacylglycerol lipase. Cholera toxin, after a lag period 30–90 min, increases accumulation accelerates breakdown. toxin inhibits guanosine triphosphatase involved conversion active inactive cyclase NAD ribosylation plasma membrane protein. addition adenosine deaminase rat rapidly activates by removing membrane-bound exerts an inhibitory constraint on basal activity. Thyroid regulate affecting coupling hormone-receptor complexes cyclase. Growth hormone process involving synthesis protein(s).
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